Sanity (and body) shattering

In Bloodborne, there's a rare but deadly effect called Frenzy which occurs when you are forced to process eldritch truth from monsters, akin to Call of Cthulhu, and are overwhelmed (represented by a filling meter). This results in a frenzy that is incredibly physically painful and deals huge damage. It's an interesting way to handle sanity blasting knowledge that would cause your head to explode, so here's an attempt to translate it into OSR/D&D games:

The one on the right is the absolute inspiration for this post.

Certain rare monster attacks cause Frenzy damage (For example, 1d6 for HD 1-3 creatures, 2d6 for 4-6 and 3d6 for 7-9+). This damage is not subtracted from HP but rather noted next to Wisdom. When it reaches the total Wisdom score, the victim takes double their Wisdom in damage (save for half). Yes, this means that characters with greater insight and perception will be more susceptible when their will eventually breaks. 1 point of frenzy can be reduced per turn in safety or 1d6 points can be healed with specialized sedative medicine.

Example of play, for fun:

Former cultist Dam the Mad (2nd level wizard, 5 Wisdom), grim mercenary Wolfgang (2nd level fighter, 9 wisdom) and inquisitive Flimbo (3rd level halfling, 11 wisdom) search for Father Almwick in the cellar beneath Harrowsby Church. The marching order is Wolfgang, Flimbo and then Dam (acting as torchbearer). Upon reaching the bottom of the steps, Wolfgang feels something... dripping from above? With mounting horror they look upward and the torchlight reveals Father Almwick (HD 3, 13 HP armour as leather+shield, 1d6 frenzy damage) now squamous, grinning with wicked, bloodied fangs and climbing the ceiling.

Initiative is rolled. The corrupted priest goes first. He leaps upon the fighter and barely beats his AC of 5, dealing 3 points of damage through whispering unfathomable truths in his ear. The fighter pushes him off and strikes him with his zweihander for 7 damage. Flimbo misses with his short sword, Dam does a single point of damage with his dagger, and Dam's player regrets using his only Sleep spell on those feral beggars. Next round, the players go first. All miss except Flimbo, who deals 3 points with a short sword slash. Almwick hits Wolfgang, pulling him forward and dealing 6 damage by telling him the secret origins of his deity. The frenzy damage reaches his total Wisdom score and he fails his save. As Wolfgang only had 11 HP, Dam screams "CRUDUX CRUO!" as he is covered with his friend's brain splatter.

This, coincidentally, is what happens if you try to have more spells than your level limit allows.